Mechanism For Degradation Of G Proteins
UCSD Researchers Determine Mechanism For Degradation Of G Proteins: "G proteins regulate everything from hormone secretion to the beating of the heart.
The researchers found that GIPN appears to specifically target G proteins for degradation and thereby regulates G protein signaling by controlling the amount of G protein expressed in the cell. This occurs via GIPN binding to the N terminus of G alpha interacting proteins (GAIP), which is the mechanism that sets the ubiquitin system in motion.
The ubiquitin system is used extensively by the cell for the turnover and degradation of proteins in both the cytoplasm, the material surrounding the nucleus, and in cell membranes. Ubiquitin, itself, is a small peptide tag that marks a protein for destruction. The interaction of GIPN and GAIP, which was also discovered by the UCSD team, is part of the machinery that places the little ubiquitin tag on a protein."
The researchers found that GIPN appears to specifically target G proteins for degradation and thereby regulates G protein signaling by controlling the amount of G protein expressed in the cell. This occurs via GIPN binding to the N terminus of G alpha interacting proteins (GAIP), which is the mechanism that sets the ubiquitin system in motion.
The ubiquitin system is used extensively by the cell for the turnover and degradation of proteins in both the cytoplasm, the material surrounding the nucleus, and in cell membranes. Ubiquitin, itself, is a small peptide tag that marks a protein for destruction. The interaction of GIPN and GAIP, which was also discovered by the UCSD team, is part of the machinery that places the little ubiquitin tag on a protein."
posted at 10/16/2005 11:14:00 AM
