Death Receptors
Death Receptors: "Signaling by Tumour Necrosis Factor Receptor-1 (TNFR1)
TNF is produced by T-cells and activated macrophages in response to infection. By ligating TNFR1, TNF can have several effects (see Figure 1). In some cells it leads to activation of NF-kB and AP-1 which leads to the induction of a number of proinflammatory and immunomodulatory genes. In some cells, however, TNF can also induce apoptosis, although receptor ligation is rarely enough on its own to initiate apoptosis as is the case with CD95 ligand binding."
TNF is produced by T-cells and activated macrophages in response to infection. By ligating TNFR1, TNF can have several effects (see Figure 1). In some cells it leads to activation of NF-kB and AP-1 which leads to the induction of a number of proinflammatory and immunomodulatory genes. In some cells, however, TNF can also induce apoptosis, although receptor ligation is rarely enough on its own to initiate apoptosis as is the case with CD95 ligand binding."
posted at 11/03/2005 12:13:00 PM
